The status of TGF-β signalling in human ovarian tissues was assessed by immunohistochemistry. Growing evidence linking activation of TGF-β pathway by homeodomain proteins prompted us to look for the possible involvement of this signalling pathway in PITX2-mediated progression of ovarian cancer. ![]() Our previous studies demonstrated increased PITX2 expression in human ovarian tumours. The homeodomain transcription factor, PITX2 is associated with cancer in different tissues. Most ovarian cancers are highly invasive in nature and the high burden of metastatic disease make them a leading cause of mortality among all gynaecological malignancies.
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